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A statistical approach to genetic epidemiology : concepts and applications / Andreas Ziegler, Inke R. König
| A statistical approach to genetic epidemiology : concepts and applications / Andreas Ziegler, Inke R. König |
| Autore | Ziegler, Andreas <1966- > |
| Pubbl/distr/stampa | Weinheim : Wiley-VCH, c2006 |
| Descrizione fisica | XXVI, 335 p. : ill. ; 24 cm |
| Disciplina | 614.4 |
| Altri autori (Persone) | König, Inke R. |
| Soggetto non controllato | Epidemiologia |
| ISBN | 3-527-31252-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-990008523200403321 |
Ziegler, Andreas <1966- >
|
||
| Weinheim : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
A statistical approach to genetic epidemiology : with access to e-learning platform by Friedrich Pahlke / / Andreas Ziegler and Inke R. König
| A statistical approach to genetic epidemiology : with access to e-learning platform by Friedrich Pahlke / / Andreas Ziegler and Inke R. König |
| Autore | Ziegler Andreas <1966-> |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Weinheim an der Bergstrasse, Germany : , : WILEY-VCH Verlag GmbH & Co., , [2010] |
| Descrizione fisica | 1 online resource (1011 p.) |
| Disciplina | 614.4 |
| Altri autori (Persone) | KönigInke R |
| Soggetto topico |
Biometria
Epidemiologia molecular Molecular epidemiology Biometry |
| ISBN |
3-527-66473-4
3-527-63366-9 3-527-63365-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; title; Copyright; Dedication; Preface; Acknowledgments; 1: Molecular Genetics; 1.1 WHAT IS THE NATURE OF GENETIC INFORMATION?; 1.2 HOW IS GENETIC INFORMATION TRANSMITTED FROM GENERATION TO GENERATION?; 1.3 WHAT IS INDIVIDUAL VARIATION IN GENETIC INFORMATION?; 1.4 PROBLEMS; URLs; 2: Formal Genetics; 2.1 WHAT ARE MENDEL'S LAWS?; 2.2 HOW ARE PHENOTYPES TRANSMITTED IN FAMILIES?; 2.3 WHICH COMPLICATIONS TO THE GENERAL INHERITANCE PATTERNS EXIST?; 2.4 WHAT IS THE LAW DETECTED BY HARDY AND WEINBERG?; 2.5 PROBLEMS; URLs; 3: Genetic Markers; 3.1 WHAT IS A GENETIC MARKER?
3.2 WHAT TYPES OF GENETIC MARKERS ARE THERE?3.3 WHAT ARE GENOTYPING METHODS FOR SINGLE NUCLEOTIDE POLYMORPHISMS?; 3.4 PROBLEMS; URLs; 4: Data Quality; 4.1 HOW CAN PEDIGREE ERRORS BE DETECTED?; 4.2 HOW CAN GENOTYPING ERRORS BE DETECTED IN FAMILY-BASED STUDIES?; 4.3 HOW SHOULD GENOTYPING ERRORS BE CHECKED IN POPULATION-BASED STUDIES USING THE HARDY-WEINBERG EQUILIBRIUM?; Algorithm 4.1.; Algorithm 4.2.; Algorithm 4.3.; 4.4 HOW CAN GENOTYPING ERRORS BE DETECTED IN HIGH-THROUGHPUT GENOTYPING STUDIES? 4.5 HOW SHOULD CLUSTER PLOTS AND HOW CAN THE QUALITY OF CLUSTERS BE INVESTIGATED IN HIGH-THROUGHPUT GENOTYPING STUDIES?4.6 PROBLEMS; URLs; 5: Genetic Map Distances; 5.1 WHAT IS PHYSICAL DISTANCE?; 5.2 WHAT IS MAP DISTANCE?; 5.3 WHAT ARE LINKAGE DISEQUILIBRIUM UNITS?; 5.4 PROBLEMS; URLs; 6: Familiality, Heritability, and Segregation Analysis; 6.1 WHAT IS THE DIFFERENCE BETWEEN THE FAMILY HISTORY METHOD AND THE FAMILY STUDY METHOD?; 6.2 HAS THE PHENOTYPE OF INTEREST A FAMILIAL COMPONENT? WHAT ARE RECURRENCE RISK RATIOS?; 6.3 WHAT IS THE CONCEPT OF HERITABILITY? 6.4 WHAT ARE TWIN STUDIES? WHAT ARE ADOPTION STUDIES?6.5 WHAT ARE CRITICAL ASPECTS WHEN INVESTIGATING FAMILIAL RESEMBLANCE?; 6.6 HOW CAN EVIDENCE FOR A MAJOR GENE EFFECT BE ESTABLISHED? HOW CAN A SEGREGATION PATTERN FOLLOWING MENDELIAN INHERITANCE BE DETERMINED?; 6.7 PROBLEMS; URLs; 7: Model-Based Linkage Analysis; 7.1 HOW CAN THE RECOMBINATION FRACTION BE ESTIMATED BETWEEN TWO GENETIC MARKERS?; 7.2 HOW CAN THE RECOMBINATION FRACTION BE ESTIMATED BETWEEN A GENETIC MARKER AND A DISEASE?; 7.3 WHAT IS SIGNIFICANT EVIDENCE OF LINKAGE?; 7.4 PROBLEMS; URLs 8: Model-Free Linkage Analysis for Dichotomous Traits8.1 WHAT IS THE BASIC IDEA OF MODEL-FREE LINKAGE ANALYSIS?; 8.2 WHY IS AFFECTED SIB-PAIR ANALYSIS REASONABLE?; 8.3 WHAT ARE COMMON TESTS FOR AFFECTED SIB-PAIR ANALYSIS?; 8.4 IS THERE AN OPTIMAL AFFECTED SIB-PAIR TEST? ARE AFFECTED SIB-PAIR TESTS RELATED TO MODEL-BASED LINKAGE TESTS?; 8.5 HOW CAN SAMPLE SIZE OR POWER BE CALCULATED FOR AN AFFECTED SIB-PAIR STUDY?; 8.6 HOW ARE MODEL-FREE METHODS EXTENDED TO MULTIPLE MARKER LOCI?; 8.7 WHAT ARE STANDARD APPROACHES FOR THE ANALYSIS OF LARGE SIBSHIPS? 8.8 HOW CAN THE AFFECTED SIB-PAIR METHOD BE EXTENDED TO ARBITRARY UNILINEAL RELATIONSHIPS? |
| Record Nr. | UNINA-9910139410503321 |
|
Ziegler Andreas <1966->
|
||
| Weinheim an der Bergstrasse, Germany : , : WILEY-VCH Verlag GmbH & Co., , [2010] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
A statistical approach to genetic epidemiology : with access to e-learning platform by Friedrich Pahlke / / Andreas Ziegler and Inke R. König
| A statistical approach to genetic epidemiology : with access to e-learning platform by Friedrich Pahlke / / Andreas Ziegler and Inke R. König |
| Autore | Ziegler Andreas <1966-> |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Weinheim an der Bergstrasse, Germany : , : WILEY-VCH Verlag GmbH & Co., , [2010] |
| Descrizione fisica | 1 online resource (1011 p.) |
| Disciplina | 614.4 |
| Altri autori (Persone) | KönigInke R |
| Soggetto topico |
Biometria
Epidemiologia molecular Molecular epidemiology Biometry |
| ISBN |
3-527-66473-4
3-527-63366-9 3-527-63365-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; title; Copyright; Dedication; Preface; Acknowledgments; 1: Molecular Genetics; 1.1 WHAT IS THE NATURE OF GENETIC INFORMATION?; 1.2 HOW IS GENETIC INFORMATION TRANSMITTED FROM GENERATION TO GENERATION?; 1.3 WHAT IS INDIVIDUAL VARIATION IN GENETIC INFORMATION?; 1.4 PROBLEMS; URLs; 2: Formal Genetics; 2.1 WHAT ARE MENDEL'S LAWS?; 2.2 HOW ARE PHENOTYPES TRANSMITTED IN FAMILIES?; 2.3 WHICH COMPLICATIONS TO THE GENERAL INHERITANCE PATTERNS EXIST?; 2.4 WHAT IS THE LAW DETECTED BY HARDY AND WEINBERG?; 2.5 PROBLEMS; URLs; 3: Genetic Markers; 3.1 WHAT IS A GENETIC MARKER?
3.2 WHAT TYPES OF GENETIC MARKERS ARE THERE?3.3 WHAT ARE GENOTYPING METHODS FOR SINGLE NUCLEOTIDE POLYMORPHISMS?; 3.4 PROBLEMS; URLs; 4: Data Quality; 4.1 HOW CAN PEDIGREE ERRORS BE DETECTED?; 4.2 HOW CAN GENOTYPING ERRORS BE DETECTED IN FAMILY-BASED STUDIES?; 4.3 HOW SHOULD GENOTYPING ERRORS BE CHECKED IN POPULATION-BASED STUDIES USING THE HARDY-WEINBERG EQUILIBRIUM?; Algorithm 4.1.; Algorithm 4.2.; Algorithm 4.3.; 4.4 HOW CAN GENOTYPING ERRORS BE DETECTED IN HIGH-THROUGHPUT GENOTYPING STUDIES? 4.5 HOW SHOULD CLUSTER PLOTS AND HOW CAN THE QUALITY OF CLUSTERS BE INVESTIGATED IN HIGH-THROUGHPUT GENOTYPING STUDIES?4.6 PROBLEMS; URLs; 5: Genetic Map Distances; 5.1 WHAT IS PHYSICAL DISTANCE?; 5.2 WHAT IS MAP DISTANCE?; 5.3 WHAT ARE LINKAGE DISEQUILIBRIUM UNITS?; 5.4 PROBLEMS; URLs; 6: Familiality, Heritability, and Segregation Analysis; 6.1 WHAT IS THE DIFFERENCE BETWEEN THE FAMILY HISTORY METHOD AND THE FAMILY STUDY METHOD?; 6.2 HAS THE PHENOTYPE OF INTEREST A FAMILIAL COMPONENT? WHAT ARE RECURRENCE RISK RATIOS?; 6.3 WHAT IS THE CONCEPT OF HERITABILITY? 6.4 WHAT ARE TWIN STUDIES? WHAT ARE ADOPTION STUDIES?6.5 WHAT ARE CRITICAL ASPECTS WHEN INVESTIGATING FAMILIAL RESEMBLANCE?; 6.6 HOW CAN EVIDENCE FOR A MAJOR GENE EFFECT BE ESTABLISHED? HOW CAN A SEGREGATION PATTERN FOLLOWING MENDELIAN INHERITANCE BE DETERMINED?; 6.7 PROBLEMS; URLs; 7: Model-Based Linkage Analysis; 7.1 HOW CAN THE RECOMBINATION FRACTION BE ESTIMATED BETWEEN TWO GENETIC MARKERS?; 7.2 HOW CAN THE RECOMBINATION FRACTION BE ESTIMATED BETWEEN A GENETIC MARKER AND A DISEASE?; 7.3 WHAT IS SIGNIFICANT EVIDENCE OF LINKAGE?; 7.4 PROBLEMS; URLs 8: Model-Free Linkage Analysis for Dichotomous Traits8.1 WHAT IS THE BASIC IDEA OF MODEL-FREE LINKAGE ANALYSIS?; 8.2 WHY IS AFFECTED SIB-PAIR ANALYSIS REASONABLE?; 8.3 WHAT ARE COMMON TESTS FOR AFFECTED SIB-PAIR ANALYSIS?; 8.4 IS THERE AN OPTIMAL AFFECTED SIB-PAIR TEST? ARE AFFECTED SIB-PAIR TESTS RELATED TO MODEL-BASED LINKAGE TESTS?; 8.5 HOW CAN SAMPLE SIZE OR POWER BE CALCULATED FOR AN AFFECTED SIB-PAIR STUDY?; 8.6 HOW ARE MODEL-FREE METHODS EXTENDED TO MULTIPLE MARKER LOCI?; 8.7 WHAT ARE STANDARD APPROACHES FOR THE ANALYSIS OF LARGE SIBSHIPS? 8.8 HOW CAN THE AFFECTED SIB-PAIR METHOD BE EXTENDED TO ARBITRARY UNILINEAL RELATIONSHIPS? |
| Record Nr. | UNINA-9910816044503321 |
|
Ziegler Andreas <1966->
|
||
| Weinheim an der Bergstrasse, Germany : , : WILEY-VCH Verlag GmbH & Co., , [2010] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||